Tolfenamic acid

Tolfenamic acid
Clinical data
AHFS/ International Drug Names
Routes of
ATC code M01AG02 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
CAS Number 13710-19-5 N
PubChem (CID) 610479
ChemSpider 530683 YesY
KEGG D01183 YesY
ECHA InfoCard 100.033.862
Chemical and physical data
Formula C14H12ClNO2
Molar mass 261.707 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland.[2] Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.[3]

It is used in the UK as a treatment for migraine.[4] It is generally not available in the US.[3] It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals.[5]


  1. Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). = P29890001443 "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities" Check |url= value (help). J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443.
  2. Pentikäinen PJ, et al Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent. Eur J Clin Pharmacol. 1981;19(5):359-65. PMID 7238564
  3. 1 2 NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
  4. NHS Tolfenamic Acid (Tolfenamic acid 200mg tablets) Page accessed July 3, 2015
  5. international listings for tolfenamic acid Page accessed July 3, 2015
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