DS-1 (drug)

CAS Number 372497-52-4 YesY
PubChem (CID) 979735
ChemSpider 849261 YesY
ECHA InfoCard 100.209.966
Chemical and physical data
Formula C18H10Br2ClN3OS
Molar mass 511.617 g/mol
3D model (Jmol) Interactive image

DS-1 is a drug from the imidazopyridine family, which is the first drug developed that acts as a GABAA receptor positive allosteric modulator (PAM) selective for the α4β3δ subtype, which is not targeted by other GABAA receptor PAMs such as the benzodiazepines or other nonbenzodiazepine drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.[1]

See also


  1. Wafford, KA; Van Niel, MB; Ma, QP; Horridge, E; Herd, MB; Peden, DR; Belelli, D; Lambert, JJ (2009). "Novel compounds selectively enhance delta subunit containing GABA a receptors and increase tonic currents in thalamus". Neuropharmacology. 56 (1): 182–9. doi:10.1016/j.neuropharm.2008.08.004. PMID 18762200.
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