CAS Number 160845-95-4 YesY
PubChem (CID) 183782
ChemSpider 159808 N
Chemical and physical data
Formula C19H29ClN2O2
Molar mass 352.9 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

RS-67,333 is a drug which has been investigated as a potential rapid-acting antidepressant,[1] nootropic,[2] and treatment for Alzheimer's disease.[3] It is a high-affinity 5-HT4 receptor partial agonist, as well as a sigma receptor ligand of both subtypes to a lesser extent.[4]


  1. Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G (2007). "Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.". Neuron. 55 (5): 71225. doi:10.1016/j.neuron.2007.07.041. PMID 17785179.
  2. Lamirault L, Simon H (2001). "Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.". Neuropharmacology. 41 (7): 84453. doi:10.1016/S0028-3908(01)00123-X. PMID 11684148.
  3. Cho S, Hu Y (2007). "Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.". Experimental Neurology. 203 (1): 2748. doi:10.1016/j.expneurol.2006.07.021. PMID 16978609.
  4. Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD (August 1995). "Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo". Br. J. Pharmacol. 115 (8): 1387–92. doi:10.1111/j.1476-5381.1995.tb16628.x. PMC 1908873Freely accessible. PMID 8564196.

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