|AHFS/Drugs.com||International Drug Names|
|ATC code||M01AG04 (WHO) M02AA18 (WHO)|
|Chemical and physical data|
|Molar mass||296.14864 g/mol|
Meclofenamic acid (meclofenamate sodium, brand Meclomen) is a drug used for joint, muscular pain, arthritis and dysmenorrhea. It is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs and was approved by the FDA in 1980. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.
Patents on the drug expired in 1985:295 and several generics were introduced in the US, but as of July 2015 only Mylan still sold it.
Use in horses
Meclofenamic acid is sold under the trade name "Arquel" for use in horses, and is administered as an oral granual form at a dose of 2.2 mg/kg/day. It has a relatively slow onset of action, taking 36–48 hours for full effect, and is most useful for treatment of chronic musculoskeletal disease. It has been found to be beneficial for the treatment of navicular syndrome, laminitis, and osteoarthritis, in some cases having a more profound effect than the commonly used NSAID phenylbutazone. However, due to cost, it is not routinely used in practice. Toxicity due to excessive dosage is similar to that of phenylbutazone, including depression, anorexia, weight loss, edema, diarrhea, oral ulceration, and decreased hematocrit.
- FDA Meclomen page at FDA Page accessed July 3, 2015
- NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015
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- United States. Congress. Office of Technology Assessment Pharmaceutical R & D: Costs, Risks & Rewards DIANE Publishing, 1993 ISBN 978-0-7881-0468-8
- FDA Meclofenamate sodium ANDAs at FDA Page accessed July 3, 2015
- FDA Mylan label for meclofenamate sodium Revised: October 2013, Accessed July 3, 2015
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- Lees P, Higgins AJ. Clinical pharmacology in therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J 1985;17:83–96.