Ro 04-6790

Ro 04-6790
Clinical data
ATC code none
CAS Number 202466-68-0
PubChem (CID) 5312145
ChemSpider 4471575
Chemical and physical data
Formula C12H16N6O2S
Molar mass 308.359 g/mol
3D model (Jmol) Interactive image

Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT6 serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,[1] Ro 04-6790 has nootropic effects in animals,[2] and reduces the amnesia produced by memory-impairing drugs such as dizocilpine[3] and scopolamine.[4]


  1. Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. doi:10.1016/j.neuropharm.2008.06.061 PMID 18655798
  2. King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology (Berlin). 2008 Oct 7. PMID 18839151
  3. Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behavioural Brain Research. 2008 Apr 9;188(2):304-9. PMID 18164078
  4. Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berlin). 2003 Dec;170(4):358-67. PMID 13680084

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