IUPAC name
2-(3-chloro-2-methylanilino)pyridine-3-carboxylic acid
Other names
Clonixic acid; CBA 93626[1]
17737-65-4 YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:76200 N[???]
ChEMBL ChEMBL1332971 N
ChemSpider 26711 N
ECHA InfoCard 100.037.921
KEGG D03555 YesY
PubChem 28718
Molar mass 262.69 g·mol−1
Legal status
  • US: Not sold in the U.S.
per os
Glucuronidation via UGT2B7
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Clonixin is a non-steroidal anti-inflammatory drug. It also has analgesic, antipyretic, and platelet-inhibitory actions. It is used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.


Clonixin synthesis: M. H. Sherlock, N. Sperber, BE 679271 ; eidem, U.S. Patent 3,337,570 (1966, 1967 both to Schering).


The glyceryl ester of clonixin, clonixeril, is also a NSAID. It was prepared by a somewhat roundabout method.

Clonixeril synthesis:[2][3]

Clonixin was reacted with chloroacetonitrile and triethylamine to give 2. Heating with potassium carbonate and glycerol actonide displaced the activating group to produce ester 3, which was deblocked in acetic acid to produce clonixeril (4).

See also


  1. The Journal of Clinical Pharmacology 11(5) (1971). "Clonixin: A Clinical Evaluation of a New Oral Analgesic". Retrieved 2015-05-21.
  2. M. H. Sherlock, ZA 6802185 (1968); Chem. Abstr., 70: 96640c (1969).
  3. CH 534129 (1973); Chem. Abstr., 79: 18582g (1973).

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