|ATC code||N05CM15 (WHO)|
|Chemical and physical data|
|Molar mass||98.143 g/mol|
|3D model (Jmol)||Interactive image|
|(what is this?)|
Methylpentynol (Methylparafynol, Dormison, Atemorin, Oblivon) is a tertiary hexanol with hypnotic/sedative and anticonvulsant effects. It was discovered by Bayer in 1913 and was used shortly thereafter for the treatment of insomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.
The drug was marketed again in the United States, Europe and elsewhere from 1956 well into the 1960s as a rapid-acting sedative; it was overshadowed at that point by benzodiazepines and the continued popularity of non-barbiturate sedatives such as meprobamate.
- DE patent 289800, "Verfahren zur Darstellung der Oxyalkylderivate von Kohlenwasserstoffen", issued 1913-11-30, assigned to Bayer, Leverkusen
- Hirsh, H. L.; Orsinger, W. H. (1952). "Methylparafynol--a new type hypnotic. Preliminary report on its therapeutic efficacy and toxicity". American practitioner and digest of treatment. 3 (1): 23–26. PMID 14903452.
- Schaffarzick, R. W.; Brown, B. J. (1952). "The anticonvulsant activity and toxicity of methylparafynol (dormison) and some other alcohols". Science. 116 (3024): 663–665. doi:10.1126/science.116.3024.663. PMID 13028241.
- Herz, A. (1954). "A new type of hypnotic; unsaturated tertiary carbinols; experimental studies on therapeutic use of 3-methyl-pentin-ol-3 (methylparafynol)". Arzneimittel-Forschung. 4 (3): 198–199. PMID 13159700.
- Weaver, L. C.; Alexander, W. M.; Abreu, B. E. (1961). "Anticonvulsant activity of compounds related to methylparafynol". Archives Internationales de Pharmacodynamie et de Thérapie. 131: 116–122. PMID 13783544.
- Richard Devenport Hines, The Pursuit of Oblivion (2002) pp 327
- W. Grimene and H. Emde, German Patent 959,485 (1957).