Hopantenic acid

Hopantenic acid
IUPAC name
4-{[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino}butanoic acid
18679-90-8 YesY
17097-76-6 (Calcium salt) YesY
3D model (Jmol) Interactive image
Interactive image
ChEMBL ChEMBL2110783
ChemSpider 26309 YesY
KEGG D08042 YesY
PubChem 28281
Molar mass 233.26 g·mol−1
Related compounds
Related alkanoic acids
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Hopantenic acid (homopantothenic acid), also known as N-pantoyl-GABA, is a central nervous system depressant. Formulated as the calcium salt, it is used as a pharmaceutical drug in the Russian Federation for a variety of neurological, psychological and psychiatric conditions and sold as Pantogam (Russian: Пантогам).[1] It is not approved for use in Europe or the United States.


Hopantenic acid is a homologue of pantothenic acid. While pantothenic acid is the amide of D-pantoate and β-alanine, hopantenic acid is the amide of D-pantoate and γ-aminobutyric acid (GABA). This change leads to an additional CH2 in the molecule.[2]

See also


  1. Pantogam, drugs.com
  2. Kopelevich VM, Evdokimova GS, Marieva TD, Shmuilovich LM (1971). "Synthesis of D-homopantothenic acid". Pharmaceutical Chemistry Journal. 5 (9): 534–536. doi:10.1007/BF00771659.

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