|Synonyms||1-Acetyl-N,N-diethyllysergamide, ALD, N-acetyl-LSD, Acetyl lysergic acid diethylamide, d-acetyl lysergic acid diethylamide, d-acetyldiethyllysergamide|
|Chemical and physical data|
|Molar mass||365.469 g/mol|
|3D model (Jmol)||Interactive image|
|(what is this?)|
ALD-52, also known as 1-acetyl-LSD, is a chemical analogue of lysergic acid diethylamide (LSD). It was originally discovered by Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.
In Entry 26 of his compendium TiHKAL, which discussed LSD, Shulgin touched briefly on the subject of ALD-52. His writings are vague, second hand accounts, saying doses in the 50–175 µg range have resulted in various conclusions. One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent. Another informant claimed it was more effective in increasing blood pressure. Yet another informant could not tell them apart.
In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD. Human experiments have not been well documented, but reports have indicated significant interference with serotonin pathways with potential long term consequences affecting memory and mood stability. Contaminants have been identified to accelerate absorption which may lead to toxicity at significantly lower levels. Failure to monitor quality and dosing can be fatal.
It is possible ALD-52 was the active chemical in the Orange Sunshine variety of LSD that was widely available in California through 1968 and 1969. The Sonoma County underground chemistry lab of Tim Scully and Nicholas Sand was Orange Sunshine's source. It was shut down by the police, and Scully was arrested and prosecuted. This resulted in the first drug analogue trial, where Scully claimed that he and his partners did nothing illegal, because they were producing ALD-52, which was not an illicit drug. However, as the prosecution claimed, there were problems with such a rationale—ALD-52 readily undergoes hydrolysis to LSD, and secondly, the synthesis of ALD-52 required LSD. (The second point was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.
On June 10, 2014 the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that ALD-52 be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use. The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.
- Lysergic acid diethylamide (LSD)
- O-Acetylpsilocin (4-AcO-DMT)
- AL-LAD (6-allyl-6-nor-lysergic acid diethylamide)
- ETH-LAD (6-ethyl-6-nor-lysergic acid diethylamide)
- PRO-LAD (6-propyl-6-nor-lysergic acid diethylamide)
- 1P-LSD (1-propionyl-lysergic acid diethylamide)