Clinical data
Routes of
By mouth (tablets)
ATC code N03AA30 (WHO)
Legal status
Legal status
Synonyms Endiemal, metharbitone, methobarbitone[1]
CAS Number 50-11-3 YesY
PubChem (CID) 4099
DrugBank DB00463 YesY
ChemSpider 3957 YesY
UNII 02OS7K758T YesY
KEGG D01382 YesY
ECHA InfoCard 100.000.011
Chemical and physical data
Formula C9H14N2O3
Molar mass 198.219 g/mol
3D model (Jmol) Interactive image

Metharbital was patented in 1905 by Emil Fischer working for Merck.[2] It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy.[3][4] It has similar properties to phenobarbital.



Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][7]


  1. The Comparative Toxicogenomics Database: Metharbital
  2. US Patent 782742
  3. The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8
  4. The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5
  5. A. Halpern, J.W. Jones, J. Am. Pharm. Assoc., 38, 352 (1949)
  6. Snyder, J. A.; Link, K. P. (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society. 75 (8): 1881. doi:10.1021/ja01104a030.
  7. U.S. Patent 782,742
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