Clinical data
AHFS/ International Drug Names
ATCvet code QN01AF90 (WHO)
Legal status
Legal status
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 14.3 h (cats)
Synonyms Thiamylal, Thioseconal, Surital
CAS Number 77-27-0 YesY
PubChem (CID) 3032285
DrugBank DB01154 YesY
ChemSpider 2297298 YesY
UNII 01T23W89FR YesY
KEGG D06106 YesY
ECHA InfoCard 100.000.927
Chemical and physical data
Formula C12H18N2O2S
Molar mass 254.35 g/mol
3D model (Jmol) Interactive image

Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia [1] or as an anticonvulsant to counteract side effects from other anaesthetics.[2] It is the thiobarbiturate analogue of secobarbital.


  1. Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
  2. Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.

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