Legal status
Legal status
  • UK: Psychoactive
  • Illegal in Denmark, Japan, Latvia, Sweden and Switzerland
CAS Number none
PubChem (CID) 119025985
ChemSpider 52085129
Chemical and physical data
Formula C23H29N3O2
Molar mass 379.501 g·mol−1
3D model (Jmol) Interactive image

1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is an analog of LSD and homolog of ALD-52 and has been sold online as a designer drug since 2015.[1][2][3][4][5][6]


While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum.[7] This implies that 1P-LSD acts as a prodrug for LSD. This partially explains the effects of 1P-LSD, because the compound itself is unable to bind to the 5-HT2A receptors responsible for the effects of psychedelic drugs.[8][9]

Prior to the publishing of the above cited research, pharmacologist David E. Nichols reportedly commented with his thoughts on 1P-LSD serotonin receptor binding:[10]

I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. The way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor.


The effects profile of 1P-LSD is not well defined. It is generally thought to be comparable to that of LSD.[11]

Legal status


1P-LSD is not scheduled by the United Nations' Convention on Psychotropic Substances.[12]


1P-LSD is illegal in Denmark.[13]


1P-LSD is illegal in Japan since 18 April 2016.[14]


1P-LSD is illegal in Latvia. Although it isn't specifically scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.[15]


1p-LSD is illegal in Finland.


1P-LSD is illegal in Sweden.[16][17]


1P-LSD is illegal in Switzerland.[18]

United Kingdom

1P-LSD is illegal in the UK under the Psychoactive Substances Act.

United States

While 1P-LSD is not controlled at the federal level in the United States, it's possible that 1P-LSD could be considered as an analog of LSD, in which case trade or possession with intent for human consumption could be prosecuted under the Federal Analogue Act.[19]

See also


  1. "Philtre Bulletin Issue 5" (PDF). WEDINOS. March 2015. Retrieved 28 July 2015.
  2. Max Daly (27 July 2015). "Why Young Brits Are Taking So Much LSD and Ecstasy". Vice. Retrieved 11 August 2015.
  3. "Newer Unregulated Drugs" (PDF). KFx. April 2015. Retrieved 13 August 2015.
  4. Matthew Speiser (11 August 2015). "A handful of dangerous new legal drugs has public health experts worried". Business Insider UK. Retrieved 13 August 2015.
  5. "1P-LSD". New Synthetic Drugs Database.
  6. Joseph J. Palamar; Patricia Acosta; Scott Sherman; Danielle C. Ompad; Charles M. Cleland (June 2016). "Self-reported use of novel psychoactive substances among attendees of electronic dance music venues". The American Journal of Drug and Alcohol Abuse: 1–9. doi:10.1080/00952990.2016.1181179. PMID 27315522.
  7. Simon D. Brandt; Pierce V. Kavanagh; Folker Westphal; Alexander Stratford; Simon P. Elliott; Khoa Hoang; Jason Wallach; Adam L. Halberstadt (October 2015). "Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)". Drug Testing and Analysis. doi:10.1002/dta.1884. PMID 26456305.
  8. Jose (15 October 2015). "Is 1P-LSD A Prodrug To LSD?". Detect-Kit. Retrieved 15 October 2015.
  9. P. Linda; A. Stener; A. Cipiciani; G. Savelli (January–February 1983). "Hydrolysis of amides. Kinetics and mechanism of the basic hydrolysis of N-acylpyrroles, N-acylindoles and N-acylcarbazoles". Journal of Heterocyclic Chemistry. 20 (1): 247–248. doi:10.1002/jhet.5570200154.
  10. kman1898 (16 February 2015). "The Big & Dandy 1P-LSD Thread, Volume 1". Bluelight.
  11. Fabrizio Schifano; Laura Orsolini; Duccio Papanti; John Corkery (June 2016). "NPS: Medical Consequences Associated with Their Intake". Current Topics in Behavioral Neurosciences. Springer International Publishing. pp. 1–30. doi:10.1007/7854_2016_15. ISSN 1866-3370. OCLC 643052237. PMID 27272067.
  12. "International Drug Control Conventions". United Nations Office on Drugs and Crime (UNODC).
  13. "Lists of euphoriant substances". The Danish Medicines Agency. September 2015.
  14. "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare.
  15. "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" (in Latvian). Latvijas Republikas tiesību akti.
  16. "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 17 November 2015.
  17. "31 nya substanser klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 26 January 2016.
  18. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.
  19. "Introduction to the Federal Controlled Substance Analogue Act". Erowid. January 2001.
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