| IUPAC name
| Other names
Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439
|3D model (Jmol)||Interactive image|
|Melting point||235-238 °C(lit.)|
| Soluble to 10 mM in 1eq. HCl
methanol: soluble 50 mg/ml
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Harmane (harman) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke. Harmane is strongly associated with Essential Tremor, one of the most common neurological diseases in the elderly. It is likely to be the main endogenous ligand for the benzodiazepine receptor. Highest concentrations are found in cooked meat (chicken, beef, pork and fish).
- Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee Life Sci. 2006 Jan 18;78(8):795-802. Epub 2005 Aug 31.
- Human monoamine oxidase is inhibited by tobacco smoke: β-carboline alkaloids act as potent and reversible inhibitors Biochemical and Biophysical Research Communications Volume 326, Issue 2, 14 January 2005, Pages 378–386.
- Elevation of blood beta-carboline alkaloids in essential tremor http://web.ics.purdue.edu/~wzheng/Publications/Epapers/2002_Louis%20et%20al%20Neurology.pdf
- 1-Methyl-beta-carboline (harmane), a potent endogenous inhibitor of benzodiazepine receptor binding Naunyn Schmiedebergs Arch. Pharmacol. 1980 Oct;314(1):97-100
- Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats
- Effect of harmane, an endogenous β-carboline, on learning and memory in rats
- Action of harman (1-methyl-beta-carboline) on the brain: body temperature and in vivo efflux of 5-HT from hippocampus of the rat
- Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness