Clinical data
ATC code N05CA07 (WHO)
Legal status
Legal status
Synonyms 5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS Number 115-44-6 YesY
PubChem (CID) 8275
DrugBank DB00306 YesY
ChemSpider 7976 YesY
ECHA InfoCard 100.003.719
Chemical and physical data
Formula C11H16N2O3
Molar mass 224.256 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.


Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.[1]

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl ionopore at the GABAA receptor, increasing the duration of time for which the Cl ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.


Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension,[1] and shock.


  1. 1 2 Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2.

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