Clinical data
AHFS/ International Drug Names
ATC code N01AX04 (WHO)
CAS Number 1421-14-3 N
PubChem (CID) 15004
ChemSpider 14283 YesY
KEGG D05626 YesY
ECHA InfoCard 100.014.384
Chemical and physical data
Formula C18H27NO5
Molar mass 337.411 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Propanidid is an ultra short-acting phenylacetate general anesthetic. It was originally introduced by Bayer in 1963[1] but anaphylactic reactions caused it to be withdrawn shortly afterwards.

Even though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.

It has been argued that the toxic effects or reactions to propanidid (and Althesin) were due to the drugs themselves.[2] Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.


  1. US patent 3086978, Hiltmann, R.; Wollweber, H.; Hoffmeister, F.; Wirth, W., "3-Methoxy-4-Carbamidomethoxy-Phenylacetic Acid Esters", issued 1963-04-23, assigned to Bayer
  2. Clarke, R. S.; Dundee, J. W.; Carson, I. W. (1973). "A New Steroid Anaesthetic - Althesin" (pdf). Proceedings of the Royal Society of Medicine. 66 (10): 1027–1030. PMC 1645602Freely accessible. PMID 4148526.
This article is issued from Wikipedia - version of the 9/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.