Clinical data
AHFS/ International Drug Names
ATC code M03BA01 (WHO)
Pharmacokinetic data
Biological half-life 5 - 8 hours
CAS Number 673-31-4 N
PubChem (CID) 4770
ChemSpider 4606 YesY
KEGG D01824 YesY
ECHA InfoCard 100.010.552
Chemical and physical data
Formula C10H13NO2
Molar mass 179.22
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate has been used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.

Doses range from 400 to 800 mg, up to 3 times a day.


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