For the song by Phoenix, see Chloroform (song).
Preferred IUPAC name
Other names
Methane trichloride
Methyl trichloride
Methenyl trichloride
Freon 20
UN 1888
67-66-3 YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:35255 YesY
ChemSpider 5977 YesY
ECHA InfoCard 100.000.603
EC Number 200-663-8
KEGG C13827 YesY
PubChem 6212
RTECS number FS9100000
UNII 7V31YC746X YesY
Molar mass 119.37 g·mol−1
Appearance Colorless liquid
Odor Heavy, ethereal odor
Density 1.564 g/cm3 (−20 °C)
1.489 g/cm3 (25 °C)
1.394 g/cm3 (60 °C)
Melting point −63.5 °C (−82.3 °F; 209.7 K)
Boiling point 61.15 °C (142.07 °F; 334.30 K)
decomposes at 450 °C
1.062 g/100 mL (0 °C)
0.809 g/100 mL (20 °C)
0.732 g/100 mL (60 °C)
Solubility Soluble in benzene
Miscible in diethyl ether, oils, ligroin, alcohol, CCl4, CS2
Solubility in acetone ≥ 10 g/100 mL (19 °C)
Solubility in dimethyl sulfoxide ≥ 10 g/100 mL (19 °C)
Vapor pressure 0.62 kPa (−40 °C)
7.89 kPa (0 °C)
25.9 kPa (25 °C)
313 kPa (100 °C)
2.26 MPa (200 °C)
3.67 L·atm/mol (24 °C)
Acidity (pKa) 15.7 (20 °C)
UV-vismax) 250 nm, 260 nm, 280 nm
Thermal conductivity 0.13 W/m·K (20 °C)
1.4459 (20 °C)
Viscosity 0.563 cP (20 °C)
1.15 D
114.25 J/mol·K
202.9 J/mol·K
-134.3 kJ/mol
-71.1 kJ/mol
473.21 kJ/mol
N01AB02 (WHO)
Main hazards carcinogen[2]
Safety data sheet See: data page
GHS pictograms
GHS signal word Warning
H302, H315, H319, H332, H336, H351, H361, H373
P261, P281, P305+351+338
Xn Xi
Carc. Cat. 2B
R-phrases R22, R38, R40, R48/20/22
S-phrases (S2), S36/37
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
1250 mg/kg (rats, oral)
9617 ppm (rat, 4 hr)[3]
20,000 ppm (guinea pig, 2 hr)
7056 ppm (cat, 4 hr)
25,000 ppm (human, 5 min)[3]
US health exposure limits (NIOSH):
PEL (Permissible)
50 ppm (240 mg/m3)[2]
REL (Recommended)
Ca ST 2 ppm (9.78 mg/m3) [60-minute][2]
IDLH (Immediate danger)
500 ppm[2]
Supplementary data page
Refractive index (n),
Dielectric constantr), etc.
Phase behaviour
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Chloroform, or trichloromethane, is an organic compound with formula CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on a large scale as a precursor to PTFE and refrigerants, but the latter application is declining.[4] It is one of the four chloromethanes and a trihalomethane.[4]


The molecule adopts tetrahedral molecular geometry with C3v symmetry.

Natural occurrence

The total global flux of chloroform through the environment is approximately 660000 tonnes per year,[5] and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil.[6]

Chloroform volatilizes readily from soil and surface water and undergoes degradation in air to produce phosgene, dichloromethane, formyl chloride, carbon monoxide, carbon dioxide, and hydrogen chloride. Its half-life in air ranges from 55 to 620 days. Biodegradation in water and soil is slow. Chloroform does not significantly bioaccumulate in aquatic organisms.[7]


The Discovery of Chloroform, sign language, 1913

Chloroform was synthesized independently by several investigators circa 1831:

In 1834, French chemist Jean-Baptiste Dumas determined chloroform's empirical formula and named it.[16] In 1835, Dumas prepared the substance by the alkaline cleavage of trichloroacetic acid. Regnault prepared chloroform by chlorination of chloromethane.

In 1842 Dr Robert Mortimer Glover in London discovered the anaesthetic qualities of chloroform on laboratory animals.[17] By the 1850s, chloroform was being produced on a commercial basis by using the Liebig procedure, which retained its importance until the 1960s. Today, chloroform — along with dichloromethane — is prepared exclusively and on a massive scale by the chlorination of methane and chloromethane.[4]


In industry, chloroform is produced by heating a mixture of chlorine and either chloromethane or methane.[4] At 400–500 °C, a free radical halogenation occurs, converting these precursors to progressively more chlorinated compounds:

CH4 + Cl2 → CH3Cl + HCl
CH3Cl + Cl2CH2Cl2 + HCl
CH2Cl2 + Cl2 → CHCl3 + HCl

Chloroform undergoes further chlorination to yield carbon tetrachloride (CCl4):

CHCl3 + Cl2 → CCl4 + HCl

The output of this process is a mixture of the four chloromethanes (chloromethane, dichloromethane, chloroform, and carbon tetrachloride), which can then be separated by distillation.[4]

Chloroform may also be produced on a small scale via the haloform reaction between acetone and sodium hypochlorite:

3 NaClO + C3H6O → CHCl3 + 2 NaOH + NaOCOCH3


Main article: Deuterated chloroform

Deuterated chloroform is an isotopologue of chloroform with a single deuterium atom. CDCl3 is a common solvent used in NMR spectroscopy. Deuterochloroform is produced by the haloform reaction, the reaction of acetone (or ethanol) with sodium hypochlorite or calcium hypochlorite.[4] The haloform process is now obsolete for the production of ordinary chloroform. Deuterochloroform can also be prepared by the reaction of sodium deuteroxide with chloral hydrate, or from ordinary chloroform.[18]

Inadvertent formation of chloroform

The haloform reaction can also occur inadvertently in domestic settings. Bleaching with hypochlorite generates halogenated compounds in side reactions; chloroform is the main byproduct.[19] Sodium hypochlorite solution (chlorine bleach) mixed with common household liquids such as acetone, butanone, ethanol, or isopropyl alcohol can produce some chloroform, in addition to other compounds such as chloroacetone or dichloroacetone.


In terms of scale, the most important reaction of chloroform is with hydrogen fluoride to give monochlorodifluoromethane (CFC-22), a precursor in the production of polytetrafluoroethylene (Teflon):[4]

CHCl3 + 2 HF → CHClF2 + 2 HCl

The reaction is conducted in the presence of a catalytic amount of mixed antimony halides. Chlorodifluoromethane is then converted into tetrafluoroethylene, the main precursor to Teflon. Before the Montreal Protocol, chlorodifluoromethane (designated as R-22) was also a popular refrigerant.


The hydrogen attached to carbon in chloroform participates in hydrogen bonding.[20][21] Worldwide, chloroform is also used in pesticide formulations, as a solvent for fats, oils, rubber, alkaloids, waxes, gutta-percha, and resins, as a cleansing agent, grain fumigant, in fire extinguishers, and in the rubber industry.[7][22] CDCl3 is a common solvent used in NMR spectroscopy.


As a reagent, chloroform serves as a source of the dichlorocarbene CCl2 group.[23] It reacts with aqueous sodium hydroxide usually in the presence of a phase transfer catalyst to produce dichlorocarbene, CCl2.[24][25] This reagent affects ortho-formylation of activated aromatic rings such as phenols, producing aryl aldehydes in a reaction known as the Reimer–Tiemann reaction. Alternatively the carbene can be trapped by an alkene to form a cyclopropane derivative. In the Kharasch addition chloroform forms the CHCl2 free radical in addition to alkenes.


Antique bottles of chloroform

The anaesthetic qualities of chloroform were first described in 1842 in a thesis by Dr Robert Mortimer Glover which won the Harveian Medal for that year. Glover also undertook practical experiments on dogs to prove his theories. Glover further refined his theories and presented them in the thesis for his doctorate at Edinburgh University in the summer of 1847. Simpson was one of the persons required to read the thesis. Simpson later claimed to have never read the thesis and to have come to his conclusions independently.

On 4 November 1847, the Scottish obstetrician James Young Simpson first used the anesthetic qualities of chloroform on a pair of humans—two guests at his dinner party. This was done as an entertainment and not as a medical procedure.[26]

A few days later, during the course of a dental procedure in Edinburgh, Francis Brodie Imlach became the first person to use chloroform on a patient in a clinical context.[27]

In May 1848 Dr Robert Halliday Gunning made a presentation to the Medico-Chirurgical Society of Edinburgh following a series of laboratory experiments on rabbits which confirmed Glover's findings and also refuted Simpson's claims of originality. However, a knighthood for Simpson, and massive media coverage of the wonders of chloroform ensured that Simpson's reputation remained high, whilst the laboratory experiments proving the dangers of chloroform were largely ignored. Gunning, who rose to be one of the richest persons in Britain, endowed some 13 university scholarships under the names of other scientists rather than his own name. Oddly (as he considered Simpson a charlatan) one of these prizes is named the Simpson Prize for Obstetrics. It is however probably a strange reverse compliment, as arguably any Simpson prize in the wider public eye should be a prize for Anaesthesia. By not calling it this he effectively snubbed Simpson whilst at the same time appearing to honour him.[28]

The use of chloroform during surgery expanded rapidly thereafter in Europe. In the 1850s, chloroform was used during the birth of Queen Victoria's last two children.[29] In the United States, chloroform began to replace ether as an anesthetic at the beginning of the 20th century; however, it was quickly abandoned in favor of ether upon discovery of its toxicity, especially its tendency to cause fatal cardiac arrhythmia analogous to what is now termed "sudden sniffer's death". Some people used chloroform as a recreational drug or to attempt suicide.[30] One possible mechanism of action for chloroform is that it increases movement of potassium ions through certain types of potassium channels in nerve cells.[31] Chloroform could also be mixed with other anesthetic agents such as ether to make C.E. mixture, or ether and alcohol to make A.C.E. mixture.

In 1848, Hannah Greener, a 15-year-old girl who was having an infected toenail removed, died after being given the anesthetic.[32] Her autopsy, establishing the cause of death was undertaken by John Fife assisted by Robert Mortimer Glover.[17] A number of physically fit patients died after inhaling it. However, in 1848 John Snow developed an inhaler that regulated the dosage and so successfully reduced the number of deaths.[33]

The opponents and supporters of chloroform were mainly at odds with the question of whether the complications were solely due to respiratory disturbance or whether chloroform had a specific effect on the heart. Between 1864 and 1910 numerous commissions in Britain studied chloroform, but failed to come to any clear conclusions. It was only in 1911 that Levy proved in experiments with animals that chloroform can cause cardiac fibrillation. The reservations about chloroform could not halt its soaring popularity. Between about 1865 and 1920, chloroform was used in 80 to 95% of all narcoses performed in the UK and the German-speaking countries. In America, however, there was less enthusiasm for chloroform narcosis. In Germany, the first comprehensive surveys of the fatality rate during anesthesia were made by Gurlt between 1890 and 1897. In 1934, Killian gathered all the statistics compiled until then and found that the chances of suffering fatal complications under ether were between 1:14,000 and 1:28,000, whereas under chloroform the chances were between 1:3,000 and 1:6,000. The rise of gas anesthesia using nitrous oxide, improved equipment for administering anesthetics and the discovery of hexobarbital in 1932 led to the gradual decline of chloroform narcosis.[34]

Criminal use

Chloroform has been reputed to be used by criminals to knock out, daze or even murder their victims. Joseph Harris was charged in 1894 with using chloroform to rob people.[35] Serial killer Dr. H. H. Holmes used chloroform overdoses to kill his female victims. In 1901, chloroform was also implicated in the murder of the American businessman William Marsh Rice, the namesake of the institution now known as Rice University. Chloroform was also deemed to be a factor in the alleged murder of a woman in 1991 when she was asphyxiated while sleeping.[36] In a 2007 plea bargain a man confessed to using stun guns and chloroform to sexually assault minors.[37] Use of chloroform as an incapacitating agent has become widely recognized, bordering on clichéd, due to the popularity of crime fiction authors having criminals use chloroform-soaked rags to render victims unconscious. However, it is nearly impossible to incapacitate someone using chloroform in this manner.[38] It takes at least five minutes of inhaling an item soaked in chloroform to render a person unconscious. Most criminal cases involving chloroform also involve another drug being co-administered, such as alcohol or diazepam, or the victim being found to have been complicit in its administration. After a person has lost consciousness due to chloroform inhalation, a continuous volume must be administered and the chin must be supported in order to keep the tongue from obstructing the airway, a difficult procedure even for an anesthesiologist. In 1865 as a direct result of the criminal reputation chloroform had gained, medical journal The Lancet offered a "permanent scientific reputation" to anyone who could demonstrate "instantaneous insensibility" using chloroform,[39] and as of 2015 no such demonstration has been forthcoming.


Chloroform is well absorbed, metabolized, and eliminated rapidly by mammals after oral, inhalation, or dermal exposure. Accidental splashing into the eyes has caused irritation.[7] Prolonged dermal exposure can result in the development of sores as a result of defatting. Elimination is primarily from lungs in the form of chloroform and carbon dioxide; less than 1% is excreted in urine.[22]

Chloroform is metabolized in the liver by the cytochrome P-450 enzymes, by oxidation to chloromethanol (which immediately turns to phosgene) and by reduction to the dichloromethyl free radical. Other metabolites of chloroform include hydrochloric acid and digluathionyl dithiocarbonate, with carbon dioxide as the predominant end product of metabolism.[40]

Chloroform causes depression of the central nervous system (CNS), ultimately producing deep coma and respiratory center depression.[40] When ingested, chloroform caused symptoms similar to those seen following inhalation. Serious illness has followed ingestion of 7.5 g (0.26 oz). The mean lethal oral dose for an adult is estimated to be about 45 g (1.6 oz).[7]

The anesthetic use of chloroform has been discontinued because it caused deaths due to respiratory and cardiac arrhythmias and failure. Following chloroform-induced anesthesia, some patients suffered nausea, vomiting, prostration, jaundice, and coma due to hepatic dysfunction. At autopsy, liver necrosis and degeneration have been observed.[7]

Chloroform has induced liver tumors in mice and kidney tumors in mice and rats.[7] The hepatotoxicity and nephrotoxicity of chloroform is thought to be due largely to phosgene.[40]

Conversion to phosgene

During prolonged storage in the presence of oxygen, chloroform converts slowly to phosgene (COCl2), releasing HCl in the process.[41]

2 CHCl3 + O2 → 2 COCl2 + 2 HCl

To prevent accidents, commercial chloroform is stabilized with ethanol or amylene, but samples that have been recovered or dried no longer contain any stabilizer. Amylene has been found ineffective, and the phosgene can affect analytes in samples, lipids, and nucleic acids dissolved in or extracted with chloroform.[42] Phosgene and HCl can be removed from chloroform by washing with saturated aqueous carbonate solutions, such as sodium bicarbonate. This procedure is simple and results in harmless products. Phosgene reacts with water to form carbon dioxide and HCl,[43] and the carbonate salt neutralizes the resulting acid.

Suspected samples can be tested for phosgene using filter paper (treated with 5% diphenylamine, 5% dimethylaminobenzaldehyde in ethanol, and then dried), which turns yellow in phosgene vapor. There are several colorimetric and fluorometric reagents for phosgene, and it can also be quantified with mass spectrometry.


It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.[44]


  1. Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 661. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4. The retained names ‘bromoform’ for HCBr3, ‘chloroform’ for HCCl3, and ‘iodoform’ for HCI3 are acceptable in general nomenclature. Preferred IUPAC names are substitutive names.
  2. 1 2 3 4 "NIOSH Pocket Guide to Chemical Hazards #0127". National Institute for Occupational Safety and Health (NIOSH).
  3. 1 2 "Chloroform". Immediately Dangerous to Life and Health. National Institute for Occupational Safety and Health (NIOSH).
  4. 1 2 3 4 5 6 7 Rossberg, M.; et al. (2005), "Chlorinated Hydrocarbons", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.a06_233.pub2
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  9. Defalque, Ray J.; Wright, A. J. (2000). "Was chloroform produced before 1831?". Anesthesiology. 92 (1): 290–291. doi:10.1097/00000542-200001000-00060. PMID 10638939.
  10. Guthrie, Samuel (1832). "New mode of preparing a spirituous solution of chloric ether". The American Journal of Science and Arts. 21: 64–65 and 405–408.
  11. Guthrie, Ossian (1887). Memoirs of Dr. Samuel Guthrie, and the History of the Discovery of Chloroform. Chicago: George K. Hazlitt & Co.
  12. Stratmann, Linda (2003). "Chapter 2". Chloroform: The Quest for Oblivion. Stroud: Sutton Publishing.
  13. Liebig, Justus von (1831). "Ueber die Zersetzung des Alkohols durch Chlor" [On the decomposition of alcohol by chlorine]. Annalen der Physik und Chemie. 99 (11): 444. doi:10.1002/andp.18310991111.
  14. Liebig, Justus von (1832). "Ueber die Verbindungen, welche durch die Einwirkung des Chlors auf Alkohol, Aether, ölbildendes Gas und Essiggeist entstehen" [On the compounds which arise by the reaction of chlorine with alcohol, ether, oil-forming gas, and spirit of vinegar]. Annalen der Physik und Chemie. 100 (2): 243. doi:10.1002/andp.18321000206.
    On pages 259–265, Liebig describes Chlorkohlenstoff ("carbon chloride", chloroform), but on p. 264, Liebig incorrectly states that the empirical formula of chloroform is C2Cl5.
  15. Soubeiran, Eugène (1831). "Recherches sur quelques combinaisons du chlore" [Investigations into some compounds of chlorine]. Annales de Chemie et de Physique (série II). 48: 113–157.
  16. Dumas, J.-B. (1834). "Récherches rélative à l'action du chlore sur l'alcool" [Experiments regarding the action of chlorine on alcohol]. L'Institut, journal général des sociétés et travaux scientifiques de la France et de l'étranger. 2: 106–108 and 112–115.
    "Es scheint mir also erweisen, dass die von mir analysirte Substance, … zur Formel hat: C2H2Cl6." (Thus it seems to me to show that the substance [that was] analyzed by me … has as [its empirical] formula: C2H2Cl6.) [Note: The coefficients of his empirical formula must be halved.]
    Dumas then notes that chloroform's simple empirical formula resembles that of formic acid. Furthermore, if chloroform is boiled with potassium hydroxide, one of the products is potassium formate. On p. 654, Dumas names chloroform:
    "Diess hat mich veranlasst diese Substanz mit dem Namen 'Chloroform' zu belegen." (This caused me to bestow this substance with the name "chloroform" [i.e., formyl chloride or chloride of formic acid].)
  17. 1 2 Defalque, R. J.; Wright, A. J. (2004). "The short, tragic life of Robert M. Glover" (PDF). Anaesthesia. 59 (4): 394–400. doi:10.1111/j.1365-2044.2004.03671.x. PMID 15023112.
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  32. Knight, Paul R., III; Bacon, Douglas R. (2002). "An Unexplained Death: Hannah Greener and Chloroform". Anesthesiology. 96 (5): 1250–1253. doi:10.1097/00000542-200205000-00030. PMID 11981167.
  33. Snow, John (1858). "On Chloroform and Other Anaesthetics and Their Action and Administration". pp. 82–85.
  34. Wawersik, J. (1997). "History of chloroform anesthesia". Anesthesiology and Reanimation. 22 (6): 144–152. PMID 9487785.
  35. "Knock-out and Chloroform". The Philadelphia Record. 9 February 1894. Retrieved 31 March 2011.
  36. "Chloroform case retrial underway". Record-Journal. 7 July 1993. Retrieved 31 March 2011.
  37. "Man admits to raping friends' daughters". USA Today. 6 November 2007. Retrieved 31 March 2011.
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  39. "Medical Annotation: Chloroform amongst Thieves". The Lancet. 2: 490–491. 1865.
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