Suriclone

Suriclone

Clinical data
ATC code	none
Identifiers
IUPAC name [6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-methylpiperazine-1-carboxylate
CAS Number	53813-83-5 N
PubChem (CID)	40903
ChemSpider	37353 Y
UNII	LNC9G689VR Y
ChEMBL	CHEMBL2105561 N
ECHA InfoCard	100.053.431
Chemical and physical data
Formula	C20H20ClN5O3S2
Molar mass	477.988 g/mol
3D model (Jmol)	Interactive image
SMILES Clc4nc5nc(N3C(=O)C=1SCCSC=1C3OC(=O)N2CCN(C)CC2)ccc5cc4
InChI InChI=1S/C20H20ClN5O3S2/c1-24-6-8-25(9-7-24)20(28)29-19-16-15(30-10-11-31-16)18(27)26(19)14-5-3-12-2-4-13(21)22-17(12)23-14/h2-5,19H,6-11H2,1H3 Y Key:RMXOUBDDDQUBKD-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Suriclone (Suril) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and pagoclone.

Suriclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties but with less amnestic effects,^[1][2] and its chemical structure is quite different from that of the benzodiazepine drugs.

The mechanism of action by which suriclone produces its sedative and anxiolytic effects is by modulating GABA_A receptors, although suriclone is more subtype-selective than most benzodiazepines.^[3]

References

1. ↑ Gilburt SJ, Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of suriclone on subjective sleep, psychomotor performance and cognitive function in young and elderly volunteers. Fundamental and Clinical Pharmacology. 1992;6(6):251-8.
2. ↑ Saletu B, Grunberger J, Linzmayer L, Semlitsch HV, Anderer P, Chwatal K. Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry. British Journal of Clinical Pharmacology. 1994 Feb;37(2):145-56.
3. ↑ Blanchard JC; Julou L. (March 1983). "Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum.". J Neurochem. 40 (3): 601–7. doi:10.1111/j.1471-4159.1983.tb08023.x. PMID 6298365.