AS-19 (drug)

CAS Number 1000578-26-6
PubChem (CID) 23642275
ChemSpider 24605931 YesY
Chemical and physical data
Formula C18H25N3
Molar mass 283.411 g/mol
3D model (Jmol) Interactive image

AS-19 is a substance which acts as a potent agonist at the 5HT7 receptor, with an IC50 of 0.83nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long term memory acquisition, but inhibits short term memory formation.[1][2]

See also


  1. Meneses, A; Perez-Garcia, G; Liy-Salmeron, G; Flores-Galvez, D; Castillo, C; Castillo, E (December 2008). "The effects of the 5-HT6 receptor agonist EMD and the 5-HT7 receptor agonist AS19 on memory formation". Behavioural Brain Research. 195 (1): 112–119. doi:10.1016/j.bbr.2007.11.023. PMID 18191236.
  2. Perez-García, G; Meneses, A (December 2008). "Ex vivo study of 5-HT1A and 5-HT7 receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia". Behavioural Brain Research. 195 (1): 139–146. doi:10.1016/j.bbr.2008.07.033. PMID 18723050.

This article is issued from Wikipedia - version of the 11/7/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.