Legal status
Legal status
CAS Number 74723-10-7
PubChem (CID) 3058221
ChemSpider 2319383
Chemical and physical data
Formula C15H10FN3O4
Molar mass 315.256 g/mol
3D model (Jmol) Interactive image

Nifoxipam (3-hydroxydesmethylflunitrazepam, DP 370) is a benzodiazepine that is a minor metabolite of flunitrazepam and has been sold online as a designer drug.[1][2][3][4][5][6][7][8][9]

Nifoxipam produces strong tranquillising and sleep-prolonging effects and has much lower toxicity compared to lormetazepam and flunitrazepam in mice.[1]

See also


  1. 1 2 Klaus Posselt, Hans Heinrich Prof. Med. Wagener, Klaus Gruber (16 October 1985). "Patent EP 0158267 A2 - Pharmaceutical composition containing 5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-7-nitro- or 5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one and process for their preparation". Retrieved 3 August 2015.
  2. "Nifoxipam". New Synthetic Drugs Database.
  3. Tansel Kilicarslan; Robert L. Haining; Allan E. Rettie; Usanda Busto; Rachel F. Tyndale; Edward M. Sellers (April 2001). "Flunitrazepam Metabolism by Cytochrome P450s 2C19 and 3A4". Drug Metabolism and Disposition. 29 (4): 460–465. PMID 11259331.
  4. Moosmann, Bjoern; King, Leslie A.; Auwärter, Volker (June 2015). "Designer benzodiazepines: A new challenge". World Psychiatry. 14 (2): 248. doi:10.1002/wps.20236. ISSN 1723-8617. PMC 4471986Freely accessible. PMID 26043347.
  5. Kevin Flemen (August 2015). "Drug Facts - Newer Unregulated Drugs" (PDF). KFx. Retrieved 15 August 2015.
  6. "Nifoxipam". WEDINOS.
  7. Markus R. Meyer; Madeleine Pettersson Bergstrand; Anders Helander; Olof Beck (May 2016). "Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes". Analytical and Bioanalytical Chemistry. 408 (13): 3571–3591. doi:10.1007/s00216-016-9439-6. PMID 27071765.
  8. Madeleine Pettersson Bergstrand, Anders Helander, Therese Hansson, Olof Beck (2016). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis. doi:10.1002/dta.2003. PMID 27366870.
  9. Katselou, Maria; Papoutsis, Ioannis; Nikolaou, Panagiota; Spiliopoulou, Chara; Athanaselis, Sotiris (2016). "Metabolites replace the parent drug in the drug arena. The cases of fonazepam and nifoxipam". Forensic Toxicology. doi:10.1007/s11419-016-0338-5. ISSN 1860-8973.

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