CAS Number 364344-56-9 YesY
PubChem (CID) 9794092
Chemical and physical data
Formula C12H14N2
Molar mass 186.25 g/mol
3D model (Jmol) Interactive image

PNU-181731 is a drug which acts as an agonist at serotonin 5-HT2 receptors,[1][2] with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM. It has anxiolytic effects in animal studies with around one tenth the potency of alprazolam and no significant ataxia or other side effects noted.[3]

See also


  1. Michael D Ennis et al. 2,3,4,5-Tetrahydro-1H-[1,4diazepino[1,7-a]indole compounds. US Patent 6734301, Priority date March 14, 2000]
  2. Junya Shirai et al. Fused heterocyclic compound and use thereof. US Patent 8158617, Priority date May 16, 2006
  3. Ennis, M. D.; Hoffman, R. L.; Ghazal, N. B.; Olson, R. M.; Knauer, C. S.; Chio, C. L.; Hyslop, D. K.; Campbell, J. E.; Fitzgerald, L. W.; Nichols, N. F.; Svensson, K. A.; McCall, R. B.; Haber, C. L.; Kagey, M. L.; Dinh, D. M. (2003). "2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-\1,4]diazepino\1,7-a]indoles: New templates for 5-HT2C agonists". Bioorganic & Medicinal Chemistry Letters. 13 (14): 2369–72. doi:10.1016/S0960-894X(03)00403-7. PMID 12824036.

This article is issued from Wikipedia - version of the 8/29/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.