Clinical data
Trade names Ansaid, Ocufen, Strepfen
AHFS/Drugs.com Monograph
MedlinePlus a687005
Routes of
ATC code M01AE09 (WHO) , M02AA19 (WHO), R02AX01 (WHO), S01BC04 (WHO)
Legal status
Legal status
  • POD
Pharmacokinetic data
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Biological half-life 4.7-5.7 hours
Excretion Renal
Synonyms (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
CAS Number 5104-49-4 YesY
PubChem (CID) 3394
DrugBank DB00712 YesY
ChemSpider 3277 YesY
KEGG D00330 YesY
ECHA InfoCard 100.023.479
Chemical and physical data
Formula C15H13FO2
Molar mass 244.261 g/mol
3D model (Jmol) Interactive image
Chirality Racemic mixture
Melting point 117 °C (243 °F)

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Side effects are analogous to those of ibuprofen.[1]

It was derived from propionic acid by the research arm of Boots UK during the 1960s, a period which also included the discovery of ibuprofen, indometacin, diclofenac, naproxen, ketoprofen, and sulindac.[2][3][4]:34

Pharmacia & Upjohn developed the drug in the US and it received FDA approval in 1988; the first generic was approved in 1994.[5]:158

As of 2016 the drug was available worldwide as drops for ophthalmic use and as tablets, both in various strengths, under many brand names which include: Acustop Cataplasma, Adofeed, Anazin, Anflupin, Anorcid, Ansaid, Antadys, Antafen, Antipain, Baenazin, Benactiv, Biprofin, Biprotec, Bro-Z, Brufen, Brufoz, Cebutid, Clinadol, Coryfin, Dispain, Edolfene, Eyeflur, Falken, Fiera, Flu Ro Fen, Flubifix, Flufen, Flugalin, Flupe, Flur di fen, Fluractive, Fluran, Flurbi Pap, Flurbic, Flurbiprofen, Flurbiprofène, Flurbiprofeno , Flurflex, Flurofen, Fluroptic, Fo Bi Pu Luo Fun, Forphen, Fortine, Froben, Frolix, Fubifen, Fubiprofen, Fubofen, Fukon, Fulruban, Furofen, Kai Fen, Kavoflog, Kotton, Lefenine, Majezik, Maprofen, Maxaljin, Maximus, Meiprofen, Neliacan, Nibelon, Nirolex Gola, Ocufen, Ocuflur, Optifen, Orofaringeo, Painil, Profen, Projezik, Ropion, Sigmaprofen, Stayban, Strefen, Strepfen, Strepflam, Strepsils (various formulations), Sulan, Tie Shr Shu, TransAct, Upnon, Urbifen, Yakuban, Zepolas, Zeralgo, Zero-P, and Zeton.[6]

As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD.[7]


  1. "Lexicomp: Flurbiprofen". Lexicomp. Wolters Kluwer. Retrieved 25 September 2015.
  2. Halford, GM; Lordkipanidzé, M; Watson, SP (2012). "50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams.". Platelets. 23 (6): 415–22. doi:10.3109/09537104.2011.632032. PMID 22098129.
  3. Rainsford KD. Fifty years since the discovery of ibuprofen. Inflammopharmacology. 2011 Dec;19(6):293-7. PMID 22120888
  4. Janos Fischer and C. Robin Ganellin. Analogue-based Drug Discovery II. John Wiley & Sons, 2010 ISBN 9783527632121
  5. Approved Drug Products with Therapeutic Equivalence Evaluations (PDF) (36th ed.). FDA. 2014.
  6. "Flurbiprofen - International Brand Names". Drugs.com. Retrieved 14 November 2016.
  7. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8. ISBN 9781284057560.

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