Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. It has been found to trigger dopamine release in the nucleus accumbens of rats.
- Phenylbiguanide is used to make amanozine and Benfosformin.
- ↑ Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats., Journal of Pharmacology and Experimental Therapeutics, 1993, PMID 8450478
- ↑ Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens., Brain Research., 1991, PMID 1711914