Clinical data
  • ?
Routes of
ATC code none
Legal status
Legal status
CAS Number 23693-38-1 YesY
PubChem (CID) 90239
ChemSpider 81465 YesY
ECHA InfoCard 100.041.645
Chemical and physical data
Formula C10H13NO3
Molar mass 195.22 g/mol
3D model (Jmol) Interactive image

Lophophine (MMDPEA, 3-methoxy-4,5-methylenedioxyphenethylamine) is a putative psychedelic and entactogen drug of the methylenedioxyphenethylamine class. It is the α-demethylated homologue of MMDA, and is also closely related to mescaline.

Alexander Shulgin originally suggested that lophophine may be a natural constituent of peyote (Lophophora williamsii) due to it being the only logical chemical intermediate for the biosynthesis of several tetrahydroisoquinolines known to be present in this cactus species.[1] Subsequently, lophophine was indeed shown to be a minor component of both peyote and San Pedro cactus.[2]

Shulgin reports that lophophine is active in the dosage range of 150–250 mg. He states that at these doses, lophophine has some similarity to mescaline in action, in producing a peaceful elevation of mood, euphoria, and mild enhancement of visual perception, but without the generation of closed-eye mental imagery. Shulgin also notes that (in contrast to mescaline), lophophine causes no nausea.[1]

At dosages above 300 mg, visual distortions that resemble those of standard doses of mescaline are said to begin to appear .

See also


  1. 1 2 A. Shulgin and A. Shulgin (1991). Pihkal, pp.701-702, Transform Press, Berkeley.
  2. Bruhn JG, El-Seedi HR, Stephanson N, Beck O, Shulgin AT (June 2008). "Ecstasy analogues found in cacti". Journal of Psychoactive Drugs. 40 (2): 219–22. doi:10.1080/02791072.2008.10400635. PMID 18720674.
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