|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|ATC code||N05BA13 (WHO)|
|Biological half-life||14 hours (halazepam), 50–100 hours (metabolites).|
|Chemical and physical data|
|Molar mass||352.7 g/mol|
|3D model (Jmol)||Interactive image|
Halazepam is a benzodiazepine derivative that was marketed under the brand names Paxipam in the United States, Alapryl in Spain, and Pacinone in Portugal.
Halazepam was used for the treatment of anxiety.
Pharmacokinetics and pharmacodynamics
|Onset of action||Intermediate to slow|
|Plasma half life||14 hr for parent drug and 30-100 hr for its metabolite|
|Peak plasma levels||1-3 hr for parent drug and 3-6 hf for its metabolite|
|Metabolism||Metabolized into desmethyldiazepam and 3-hydroxyhalazepam (in the liver)|
|Excretion||Excreted through kidneys|
|Protein binding||98% bound to plasma protein|
Halazepam was invented by Schlesinger Walter in the U.S. It was marketed as an anti-anxiety agent in 1981. However, Halazepam is not commercially available in the United States because it was withdrawn by its manufacturer for poor sales.
- Quazepam, fletazepam, triflubazam — benzodiazepines with trifluoromethyl group attached
- "halazepam". Drugs.com. Retrieved December 11, 2014.
- "Alapryl". Drugs.com. Retrieved December 11, 2014.
- "Pacinone". Drugs.com. Retrieved December 11, 2014.
- Quitkin, Frederick M. ... (1998). Current therapeutic drugs (2nd ed.). Washington: American Psychiatric Press. p. 166. ISBN 0880489944.
- "SCHEDULES OF CONTROLLED SUBSTANCES". Code of Federal Reguations. 2012-04-01. pp. § 1308.14 Schedule IV. Retrieved December 12, 2014.