Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a684001
  • ?
Routes of
ATC code N05BA13 (WHO)
Legal status
Legal status
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 14 hours (halazepam), 50–100 hours (metabolites).
Excretion Renal
Synonyms 9-chloro-6-phenyl-2-(2,2,2-trifluoroethyl)-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
CAS Number 23092-17-3 YesY
PubChem (CID) 31640
DrugBank DB00801 YesY
ChemSpider 29343 YesY
UNII 320YC168LF YesY
KEGG D00338 YesY
ECHA InfoCard 100.041.281
Chemical and physical data
Formula C17H12ClF3N2O
Molar mass 352.7 g/mol
3D model (Jmol) Interactive image

Halazepam is a benzodiazepine derivative that was marketed under the brand names Paxipam in the United States,[1] Alapryl in Spain,[2] and Pacinone in Portugal.[3]

Medical uses

Halazepam was used for the treatment of anxiety.[1]

Adverse effects

Adverse effects include drowsiness, confusion, dizziness, and sedation. Gastrointestinal side effects have also been reported including dry mouth and nausea.[1]

Pharmacokinetics and pharmacodynamics

Pharmacokinetics and pharmacodynamics were listed in Current Psychotherapeutic Drugs published in June 15, 1998 as follows:[4]

Onset of action Intermediate to slow
Plasma half life 14 hr for parent drug and 30-100 hr for its metabolite
Peak plasma levels 1-3 hr for parent drug and 3-6 hf for its metabolite
Metabolism Metabolized into desmethyldiazepam and 3-hydroxyhalazepam (in the liver)
Excretion Excreted through kidneys
Protein binding 98% bound to plasma protein

Regulatory Information

Halazepam is classified as a schedule 4 controlled substance with a corresponding code 2762 by the Drug Enforcement Administration (DEA).[5]

Commercial production

Halazepam was invented by Schlesinger Walter in the U.S. It was marketed as an anti-anxiety agent in 1981. However, Halazepam is not commercially available in the United States because it was withdrawn by its manufacturer for poor sales.[1]

See also


  1. 1 2 3 4 "halazepam". Drugs.com. Retrieved December 11, 2014.
  2. "Alapryl". Drugs.com. Retrieved December 11, 2014.
  3. "Pacinone". Drugs.com. Retrieved December 11, 2014.
  4. Quitkin, Frederick M. ... (1998). Current therapeutic drugs (2nd ed.). Washington: American Psychiatric Press. p. 166. ISBN 0880489944.
  5. "SCHEDULES OF CONTROLLED SUBSTANCES". Code of Federal Reguations. 2012-04-01. pp. § 1308.14 Schedule IV. Retrieved December 12, 2014.
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