|Chemical and physical data|
|Molar mass||153.196 g/mol|
|3D model (Jmol)||Interactive image|
|(what is this?)|
2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug. 2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood–brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute.
The Federal Analog Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended (ref 1) for human consumption. 2-FA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act.
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- B.E. Smart (2001). "Fluorine substituent effects (on bioactivity". Journal of Fluorine Chemistry. 109: 3–11. doi:10.1016/s0022-1139(01)00375-x.
- F.M.D. Ismail (2002). "Important ﬂuorinated drugs in experimental and clinical use". Journal of Fluorine Chemistry. 118: 27–33. doi:10.1016/s0022-1139(02)00201-4.
- E. Costa and S. Garattini (1970) Amphetamines and Related Compounds, p.28, New York: Raven Press.
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.