NEFA (drug)

PubChem (CID) 57426056
Chemical and physical data
Formula C15H19N
Molar mass 213.3181 g/mol
3D model (Jmol) Interactive image

NEFA is a moderate affinity NMDA antagonist (IC50 = 0.51 μM). It is a structural analog of phencyclidine.[1] It was first synthesized by a team at Parke Davis in the late 1950s.[2]


  1. Dilmore JG, Johnson JW (1998). "Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine". Biophysical Journal. 75 (4): 1801–16. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852Freely accessible. PMID 9746522.
  2. GB Patent 893920 - Polycyclic amino compounds and methods for their production

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