Clinical data
ATC code none
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 829-74-3 N
PubChem (CID) 164739
DrugBank DB06707 YesY
ChemSpider 144416 YesY
UNII V008L6478D YesY
KEGG D02388 YesY
ECHA InfoCard 100.113.606
Chemical and physical data
Formula C9H13NO3
Molar mass 183.204 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Corbadrine (INN; marketed as Neo-Cobefrine), also known as levonordefrin (USAN) and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States,[1][2] (usually in a pre-mixed solution with local anesthetics, such as mepivacaine).[3]

Corbadrine is also a metabolite of the antihypertensive drug methyldopa,[4] and plays a role in its pharmacology and effects.

See also


  1. Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 164–. ISBN 978-0-7514-0499-9.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 275–. ISBN 978-3-88763-075-1.
  3. "DailyMed — Search results for levonordefrin". DailyMed. Retrieved 20 February 2016.
  4. Sjoerdsma, A; Vendsalu, A; Engelman, K; Watts, D (1 October 1963). "Studies on the Metabolism and Mechanism of Action of Methyldopa". Circulation. 28 (4): 492–502. doi:10.1161/01.CIR.28.4.492.

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