Clinical data
AHFS/ International Drug Names
Routes of
Oral (tablets)
ATC code none
Legal status
Legal status
  • ℞-only (JP)
CAS Number 71771-90-9
PubChem (CID) 71754
ChemSpider 64795
KEGG D02614
ECHA InfoCard 100.163.233
Chemical and physical data
Formula C18H23NO4
Molar mass 317.37 g/mol
3D model (Jmol) Interactive image

Denopamine (INN) is a cardiotonic drug which acts as a β1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary oedema.[4] It is marketed in Japan under the brand name Kalgut (カルグート) and available as tablets of 5 and 10 mg, and 5% fine granules.[5]


  1. Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507
  2. Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812
  3. Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531
  4. Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398
  5. "Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information" (PDF) (in Japanese). Mitsubishi Tanabe Pharma Corporation. Retrieved 6 March 2016.
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