Clinical data
ATC code none
CAS Number 3563-92-6
PubChem (CID) 71129
ChemSpider 64277 YesY
UNII 8N66VC535R YesY
Chemical and physical data
Formula C14H21NO
Molar mass 219.32264 g/mol
3D model (Jmol) Interactive image

Zylofuramine[1] is a stimulant drug. It was developed in 1961,[2][3] and was intended for use as an appetite suppressant and for the treatment of senile dementia in the elderly, but there is little information about it and it does not appear to have ever been marketed.[4]

Zylofuramine is legal throughout the world. Its chemical structure has a vague similarity to other N-ethyl substituted stimulant drugs such as ethylamphetamine, but its structure would probably not be close enough for it to be considered a controlled substance analogue.


  1. US patent 3091621, Clarke, R. L., "Alpha-Aryl or Aralkyl Tetrahydrofurfurylamines", issued 1963-05-28, assigned to Sterling Drugs
  2. Clarke, R. L.; Harris, L. S. (1962). "α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. I". Journal of Medicinal Chemistry. 5 (1): 77–95. doi:10.1021/jm01236a010. PMID 14046619.
  3. Clarke, R. L.; Tullar, B. F.; Harris, L. S. (1962). "α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. II. Resolution of Isomers". Journal of Medicinal Chemistry. 5 (2): 362–372. doi:10.1021/jm01237a014. PMID 14051912.
  4. Harris, L. S.; Clarke, R. L.; Dembinski, J. R. (1963). "α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. III. The Pharmacology of D-Threo α-Benzyl-N-Ethyltetrahydrofurfurylamine (Zylofuramine)". Archives Internationales de Pharmacodynamie et de Thérapie. 146: 392–405. PMID 14099588.

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