Clinical data
ATC code none
Legal status
Legal status
  • Uncontrolled
CAS Number 86820-21-5 N
PubChem (CID) 1862
ChemSpider 1792 YesY
Chemical and physical data
Formula C8H10FNO3
Molar mass 187.17 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

6-Fluoronorepinephrine (6-FNE) is a selective α1 and α2 adrenergic receptor full agonist related to norepinephrine.[1][2] It is the only selective full agonist for the α adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1 adrenergic receptors.[2][3]


  1. Kirk KL, Cantacuzene D, Nimitkitpaisan Y, McCulloh D, Padgett WL, Daly JW, Creveling CR (1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry. 22 (12): 1493–7. doi:10.1021/jm00198a012. PMID 231654.
  2. 1 2 3 Stone EA, Lin Y, Sarfraz Y, Quartermain D (2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus α1-adrenoceptors by a full agonist". Brain Research. 1291: 21–31. doi:10.1016/j.brainres.2009.07.049. PMC 2735576Freely accessible. PMID 19632210.
  3. Stone EA, Grunewald GL, Lin Y, Ahsan R, Rosengarten H, Kramer HK, Quartermain D (2003). "Role of epinephrine stimulation of CNS α1-adrenoceptors in motor activity in mice". Synapse. 49 (1): 67–76. doi:10.1002/syn.10212. PMID 12710017.

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