Clinical data
AHFS/ International Drug Names
ATCvet code QV03AB90 (WHO)
Legal status
Legal status
  • Veterinary use only
CAS Number 104054-27-5 N
PubChem (CID) 71310
ChemSpider 64427 YesY
KEGG D03002 YesY
Chemical and physical data
Formula C14H16N2
Molar mass 212.290 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Atipamezole (brand name Antisedan, Pfizer) is a synthetic α2 adrenergic receptor antagonist, indicated for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs.[1]

It has also been researched in humans as a potential anti-Parkinsonian drug.[2]


In a study using New Zealand white rabbits, the optimal dose for revival of sedation by a medetomidine-ketamine mixture was found to be equal to or double the dose of medetomidine.[3]

See also


  1. Pfizer Animal Health ANTISEDAN Product Overview Archived June 17, 2008, at the Wayback Machine.
  2. Pertovaara A, Haapalinna A, Sirviö J, Virtanen R (2005). "Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist". CNS Drug Reviews. 11 (3): 273–88. doi:10.1111/j.1527-3458.2005.tb00047.x. PMID 16389294.
  3. Kim MS; et al. (2004). "Reversal of Medetomidine-Ketamine Combination Anesthesia in Rabbits by Atipamezole". Experimental Animals. 53 (5): 423–428. doi:10.1538/expanim.53.423.

External links

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