| IUPAC name
|3D model (Jmol)||Interactive image|
|Molar mass||377.50 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Sulfinalol is a beta adrenergic receptor antagonist.
The methyl group on a sulfoxide is sufficiently acidic to substitute for phenolic hydroxyl.
The preparation of this combined α- and β-blocker sulfinalol begins by protection of the phenolic hydroxyl as its benzoate ester. Bromination followed by condensation with 4-(4-methoxyphenyl)butan-2-amine (not PMA) gives the aminoketone 3. Successive catalytic reduction and saponification affords aminoalcohol 4. Oxidation of the sulfide to the sulfoxide with a reaagent such as metaperiodate gives sulfinalol (5).