Clinical data
Trade names Benfuran, Bentos, Betaclar, Glauconex
AHFS/ International Drug Names
ATC code S01ED06 (WHO)
CAS Number 39552-01-7 YesY
PubChem (CID) 2309
DrugBank DB09013 N
ChemSpider 2219 YesY
UNII 418546MT3A YesY
KEGG D07496 YesY
Chemical and physical data
Formula C16H21NO4
Molar mass 291.342 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Befunolol (INN) is a beta blocker with intrinsic sympathomimetic activity used in the management of open-angle glaucoma.[1] It also acts as a β adrenoreceptor partial agonist.[2][3] Befunolol was introduced in Japan in 1983 by Kakenyaku Kako Co. under the trade name Bentos.[4]


  1. Stephan Reichl, Christel C Müller-Goymann (2 January 2003). "The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride". International Journal of Pharmaceutics. 250 (1): 191–201. doi:10.1016/S0378-5173(02)00541-0.
  2. Koike, K; Takayanagi, I (October 1986). "A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites". Japanese Journal of Pharmacology. 42 (2): 325–8. doi:10.1254/jjp.42.325. PMID 2879061.
  3. Takayanagi, I; Koike, K (January 1985). "A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs". General Pharmacology: The Vascular System. 16 (3): 265–267. doi:10.1016/0306-3623(85)90080-1.
  4. Pharmaceutical Manufacturing Encyclopedia (3rd revised ed.). Norwich, N.Y.: William Andrew Publishing. January 14, 2008. p. 542. ISBN 978-0815515265.

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