Clinical data
AHFS/ International Drug Names
Routes of
ATC code C04AB02 (WHO) M02AX02 (WHO) QV03AB94 (WHO)
CAS Number 59-98-3 YesY
PubChem (CID) 5504
DrugBank DB00797 YesY
ChemSpider 5303 YesY
KEGG D08614 YesY
ChEBI CHEBI:28502 YesY
ECHA InfoCard 100.000.408
Chemical and physical data
Formula C10H12N2
Molar mass 160.216 g/mol
3D model (Jmol) Interactive image
For other uses, see Adrenergics.

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with Sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A agonist drugs such as 25I-NBOMe, DOB and Bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated).[1][2]

It is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation.[3][4]


  1. Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. Journal of the American Medical Association 1983 Mar 18;249(11):1477-9. PMID 6827726
  2. Thorlacius K, Borna C, Personne M. Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case. (Swedish) Lakartidningen. 2008 Apr 16-22;105(16):1199-200. PMID 18522262
  3. Boothe DM (2001). "Anticonvulsant drugs and analeptic agents". In Adams HR. Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. pp. 378–9. ISBN 0-8138-1743-9. Retrieved September 8, 2008 through Google Book Search.
  4. Hall LW, Clarke KW, Trim CM (2001). "Principles of sedation, analgesia and premedication". Veterinary anaesthesia. Philadelphia: W.B. Saunders. pp. 90–1. ISBN 0-7020-2035-4. Retrieved September 8, 2008 through Google Book Search.
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