IUPAC name
3D model (Jmol) Interactive image
ChemSpider 117130
PubChem 132673
Molar mass 468.56 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.[1]

Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.[2]

See also


  1. Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies.". Naunyn Schmiedebergs Arch Pharmacol. 334 (4): 383–7. PMID 2950328.
  2. Moy LY; et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.". J Pharmacol Exp Ther. 320 (2): 747–56. doi:10.1124/jpet.106.110791.

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