Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. The drug is a Histamine H1 receptor antagonist: selectively binding to but not activating the receptor, therby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
- ↑ Abelson MB, Allansmith MR, Friedlaender MH (1980). "Effects of topically applied ocular decongestant and antihistamine". Am J Ophthalmol. 90 (2): 254–7. PMID 7425039.
- ↑ Noguchi, Seiji; Inukai, Toshiya; Kuno, Takayoshi; Tanaka, Chikako. "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f.