Clinical data
AHFS/ International Drug Names
ATC code N06BX01 (WHO)
CAS Number 51-68-3 YesY
PubChem (CID) 4039
ChemSpider 3899 N
KEGG D00993 YesY
ECHA InfoCard 100.000.107
Chemical and physical data
Formula C12H16ClNO3
Molar mass 257.713
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Meclofenoxate (INN, BAN) (brand name Lucidril), also known as centrophenoxine, is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease.[1][2][3] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish, while pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

In elderly patients, meclofenoxate has been found clinically to improve memory, have a mentally stimulating effect, and improve general cognition.[4] Meclofenoxate also increases cellular membrane phospholipids. Although meclofenoxate is generally considered to be a dietary supplement, in some European countries, such as Germany, Hungary, and Austria, as well as Japan, it is a prescription drug.[3]

Side effects

Meclofenoxate is considered to be very safe and high in tolerability.[3] However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may due to overdosage, and may indicate the need for the dosage to be reduced.[3]


Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 30–50%, and thus may be anti-aging drugs/supplements.[5]

Brand names

In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[6]

See also


  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1.
  3. 1 2 3 4 Maija Haavisto (1 May 2008). Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia. pp. 167–. ISBN 978-1-4092-0335-3.
  4. Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing. 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
  5. The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. 1 January 2003. pp. 66–. ISBN 978-0-9668937-3-1.
  6. Yong Zhou (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN 978-1-4831-9193-5.

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