IUPAC name
174643-75-5 N
3D model (Jmol) Interactive image
ChEMBL ChEMBL338733 YesY
ChemSpider 8127716 YesY
PubChem 9952105
Molar mass 385.55 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine is a stimulant of the piperidine class which acts as a potent and selective dopamine reuptake inhibitor.[1][2] It is closely related to vanoxerine and GBR-12,935, which in contrast are piperazines.

See also


  1. Dutta AK, Coffey LL, Reith ME (January 1997). "Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity". Journal of Medicinal Chemistry. 40 (1): 35–43. doi:10.1021/jm960638e. PMID 9016326.
  2. Dutta AK, Davis MC, Fei XS, Beardsley PM, Cook CD, Reith ME (January 2002). "Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules". Journal of Medicinal Chemistry. 45 (3): 654–62. doi:10.1021/jm010316x. PMID 11806716.

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