|AHFS/Drugs.com||International Drug Names|
|ATC code||A03AX10 (WHO)|
|CAS Number||503-01-5 Y|
|Chemical and physical data|
|Molar mass||141.254 g/mol|
|3D model (Jmol)||Interactive image|
Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins). Along with paracetamol, dichloralphenazone and dimethylamylamine, it is one of the constituents of Amidrine.
Mechanism of action
Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.