Corynanthine, also known as rauhimbine, is an alkaloid found in the Rauwolfia and Pausinystalia (formerly known as Corynanthe) genera of plants. It is one of the two diastereoisomers of yohimbine, the other being rauwolscine. It is also related to ajmalicine.
Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist with approximately 10-fold selectivity for the former site over the latter. This is in contrast to yohimbine and rauwolscine which have around 30-fold higher affinity for α2-adrenergic over α1-adrenergic. As a result, corynanthine is not a stimulant (or an aphrodisiac for that matter), but a depressant, and likely plays a role in the antihypertensive properties of Rauwolfia extracts. Like yohimbine and rauwolscine, corynanthine has also been shown to possess some activity at serotonin receptors.
- ↑ PHILLIPS DD, CHADHA MS (September 1955). "The alkaloids of Rauwolfia serpentina Benth". Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 44 (9): 553–67. doi:10.1002/jps.3030440912. PMID 13251932.
- ↑ "Alkaloids from Rauvolfia canescens; Pharmaceutical Biology - 39(3):Pages 239-240 - Informa Healthcare".
- 1 2 3 Shepperson NB, Duval N, Massingham R, Langer SZ (November 1981). "Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog". The Journal of Pharmacology and Experimental Therapeutics. 219 (2): 540–6. PMID 6270312.
- 1 2 3 Doxey JC, Lane AC, Roach AG, Virdee NK (February 1984). "Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine". Naunyn-Schmiedeberg's Archives of Pharmacology. 325 (2): 136–44. doi:10.1007/bf00506193. PMID 6144048.
- ↑ Feuerstein TJ, Hertting G, Jackisch R (May 1985). "Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT-receptor agonists". Naunyn-Schmiedeberg's Archives of Pharmacology. 329 (3): 216–21. doi:10.1007/bf00501871. PMID 2991775.