Clinical data
Routes of
ATC code none
Legal status
Legal status
  • Uncontrolled
CAS Number 89303-63-9 N
PubChem (CID) 71770
ChemSpider 64808 YesY
Chemical and physical data
Formula C20H29N3
Molar mass 311.46 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Atiprosin (AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]

See also


  1. 1 2 David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
  2. Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry. 30 (2): 388–94. doi:10.1021/jm00385a022. PMID 3806618.
  3. 1 2 Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology. 10 (3): 249–58. doi:10.1097/00005344-198709000-00001. PMID 2444771.
  4. Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology. 10 (3): 341–9. doi:10.1097/00005344-198709000-00014. PMID 2444784.
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