Legal status
Legal status
CAS Number 784118-64-5
PubChem (CID) 51529346
ChemSpider 21106218
Chemical and physical data
Formula C14H23N
Molar mass 205.35 g·mol−1
3D model (Jmol) Interactive image

(-)-1-Phenyl-2-propylaminopentane (also known as (-)-PPAP and N,α-dipropylphenethylamine)[1][2][3] is a stimulant of the phenethylamine and amphetamine classes with an unusual effects profile and mechanism of action.[4]

(-)-PPAP is classified as a monoaminergic activity enhancer that stimulates the impulse propagation mediated transmitter release of the neurotransmitters dopamine, norepinephrine and serotonin in the brain. Unlike stimulants such as amphetamine, which release a flood of monoamine neurotransmitters in an uncontrolled manner, (-)-PPAP instead only increases the amount of neurotransmitters that get released when a neuron is stimulated by receiving an impulse from a neighbouring neuron. Both amphetamine and (-)-PPAP promote the release of monoamines and deuteramines, however while amphetamine causes neurons to dump neurotransmitter stores into the synapse regardless of external input, (-)-PPAP does not influence the pattern of neurotransmitter release and instead releases a larger amount of neurotransmitters than normal.[5]

(-)-PPAP has no monoamine oxidase inhibitory activity.[6]

See also


  1. Jozsef Knoll (15 June 1993). "Patent US 5220068 - Psychostimulant agent".
  2. Fumio Yoneda (10 April 2001). "Patent US 6214859 - Ethylamine derivatives".
  3. Jozsef Knoll (24 December 2001). "Patent US 5075338 - Method of treatment of learning deficiency".
  4. Knoll J, Knoll B, Török Z, Timár J, Yasar S (March–April 1992). "The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant.". Archives internationales de Pharmacodynamie et de Thérapie (316): 5–29. PMID 1356324.
  5. Joseph Knoll; Ildikó Miklya; Berta Knoll; Raissa Markó; Károly Kelemen (February 1996). "(−)Deprenyl and (−)1-phenyl-2-propylaminopentane, [(−) PPAP] act primarily as potent stimulants of action potential — transmitter release coupling in the catecholaminergic neurons". Life Sciences. 58 (10): 817–827. doi:10.1016/0024-3205(96)00014-8. PMID 8602114.
  6. G. Csaba; P. Kovács; Éva Pállinger (January–February 2006). "Acute and delayed effect of (−) deprenyl and (−) 1-phenyl-2-propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells)". Cell Biochemistry and Function. 24 (1): 49–53. doi:10.1002/cbf.1183. PMID 15584092.

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