Clinical data
Trade names Domin
AHFS/Drugs.com International Drug Names
Routes of
ATC code none
Legal status
Legal status
  • ℞ (Prescription only)
Synonyms Alefexole
CAS Number 36085-73-1 N
PubChem (CID) 5374
ChemSpider 5181 N
Chemical and physical data
Formula C10H15N3S
Molar mass 209.31 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996.[1] As of December 2014 it was not approved for marketing in the US nor in Europe.[2]

Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors. It also is an α2-adrenergic agonist.[3]

The main side effects are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints.[3] In 2008 the Japanese Ministry of Health, Labour, and Welfare mandated that Boehringer add a warning to the label concerning the risk of sudden onset of sleep.[4]:15


  1. PharmaLetter 22 July 1996 First Launch In Japan For Talipexole
  2. EvaluatePharma Database. Page accessed 9 December 2014
  3. 1 2 Benkert O, et al. Dopamine agonists in schizophrenia: a review. Eur Neuropsychopharmacol. 1995;5 Suppl:43-53. PMID 8775758
  4. Japanese Ministry of Health, Labour and Welfare March 2008 Pharmaceuticals and Medical Devices Safety Information No. 245

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