Hyoscine butylbromide

Hyoscine butylbromide
Clinical data
Trade names Buscopan
Routes of
By mouth, rectal, intravenous
ATC code A03BB01 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability <1%
Protein binding Low
Biological half-life 5 hours
Excretion Renal (50%) and fecal
CAS Number 149-64-4 YesY
PubChem (CID) 160883
DrugBank DB09300 YesY
ChemSpider 16736107 YesY
ECHA InfoCard 100.005.223
Chemical and physical data
Formula C21H30NO4+
Molar mass 360.467 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Hyoscine butylbromide, also known as scopolamine butylbromide[1] and sold under the brandname Buscopan,[2] is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms.[2][3] It is also used to improve respiratory secretions at the end of life.[4] Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein.[2]

Side effects may include sleepiness, vision changes, triggering of glaucoma, and severe allergies.[2] Sleepiness however, is uncommon.[5] It is unclear if it is safe in pregnancy.[2] It is an anticholinergic agent,[2] which does not have much effect on the brain.[6]

It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[7] It is not available in the United States.[8] The wholesale cost in the developing world is 0.004 to 0.11 USD per pill as of 2014.[9] It is manufactured from hyoscine which occurs naturally in the plant deadly nightshade.[10]

Medical uses


Hyoscine butylbromide is effective in treating crampy abdominal pain.[11]

Hyoscine butylbromide is effective in reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.[12]

It is also used during abdominal or pelvic MRI or CT scans to improve the quality of pictures.[13]


It is a quaternary ammonium compound and a semisynthetic derivative of hyoscine hydrobromide (scopolamine). The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable central nervous system side effects associated with scopolamine/hyoscine.


Hyoscine butylbromide is not centrally active and has a low incidence of abuse.


  1. Juo, Pei-Show (2001). Concise Dictionary of Biomedicine and Molecular Biology. (2nd ed.). Hoboken: CRC Press. p. 570. ISBN 9781420041309.
  2. 1 2 3 4 5 6 "Buscopan Tablets and Ampoules". Therapeutic Goods Administration, Australia. 8 November 2010. Retrieved 22 October 2013.
  3. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 270. ISBN 9781284057560.
  4. Paice, Judith (2015). Care of the Imminently Dying. Oxford University Press. p. 43. ISBN 9780190244309.
  5. Handbook of Palliative Care (3rd ed.). New York: Wiley. 2012. p. 570. ISBN 9781118426814.
  6. Hanks, Geoffrey (2011). Oxford textbook of palliative medicine (4th ed.). Oxford [etc.]: Oxford University Press. p. 805. ISBN 9780199693146.
  7. "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
  8. Territo, editor, Dennis A. Casciato ; associate editor, Mary C. (2012). Manual of clinical oncology (7th ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health. p. 146. ISBN 9781451115604.
  9. "Hyoscine Butylbromide". International Drug Price Indicator Guide. Retrieved 4 December 2015.
  10. Twycross, Robert (2003). Introducing palliative care (4th ed.). Oxford: Radcliffe Medical Press. p. 172. ISBN 9781857759150.
  11. Tytgat, G. N. (2007). "Hyoscine Butylbromide: A Review of its Use in the Treatment of Abdominal Cramping and Pain". Drugs. 67 (9): 1343–1357. doi:10.2165/00003495-200767090-00007. PMID 17547475.
  12. Samuels, L. A.; Christie, L.; Roberts-Gittens, B.; Fletcher, H.; Frederick, J. (2007). "The effect of hyoscine butylbromide on the first stage of labour in term pregnancies". BJOG. 114 (12): 1542–1546. doi:10.1111/j.1471-0528.2007.01497.x. PMID 17903230.
  13. "Hyoscine butylbromide (Buscopan®)" (PDF). UK: Guy's and St Thomas' NHS Foundation Trust. July 2014. Retrieved 16 June 2016.
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