Dopamine antagonist

Dopamine receptor antagonist
Dopaminergic blockers
Drug class


Class identifiers
Use Schizophrenia, bipolar disorder, nausea and vomiting, etc.
ATC code N05A
Biological target Dopamine receptors
External links
MeSH D012559
In Wikidata

A dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis. Several other dopamine antagonists are antiemetics used in the treatment of nausea and vomiting.

Uses and examples

Clozapine, a second generation antipsychotic

Dopamine receptor antagonists are used for some diseases such as schizophrenia, bipolar disorder, nausea and vomiting. It can also control the symptoms of hypersexuality and increased orgasmic activity.

Antidopaminergics such as haloperidol can be an antidote for poisoning with cocaine, amphetamines and dopamine agonists such as bromocriptine and/or ropinirole.

Side effects

They may include one or more of the following and last indefinitely even after cessation of the dopamine antagonist, especially after long-term or high-dosage use:


Examples of Dopamine antagonists include:[3]

See also


  1. Zisapel, N (2001). "Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting". Cellular and Molecular Neurobiology. 21 (6): 605–16. PMID 12043836.
  2. Willis, GL (2008). "Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process". Reviews in the Neurosciences. 19 (4–5): 245–316. PMID 19145986.
  3. MeSH list of agents 82018492
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