Not to be confused with doravirine.
Clinical data
Trade names No-Spa
AHFS/Drugs.com International Drug Names
Routes of
Oral, intravenous, intramuscular
ATC code A03AD02 (WHO)
Legal status
Legal status
  • OTC (tablets), ℞-only (solution for injection) (RU)[1]
Pharmacokinetic data
Bioavailability Highly variable (~65%), peak at 45–60 min
Protein binding 95–98%
Metabolism Hepatic
Biological half-life 7–16 hours
Excretion >50% in urine and ~30% in bile[1]
CAS Number 14009-24-6 N
PubChem (CID) 1712095
DrugBank DB06751 YesY
ChemSpider 1361582 YesY
KEGG D07879 YesY
ECHA InfoCard 100.130.526
Chemical and physical data
Formula C24H31NO4
Molar mass 397.507 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.[2]:283

It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[3]

It is available in Asian and Eastern European countries under several brand names, with No-Spa being one of them.[4][5]

An article from 2013 described the effects from overdose (in a 19-year-old woman) as including vomiting, seizures and fatal cardiac toxicity.[6]

In 2016, the young Russian chess player Ivan Bukavshin died of a massive overdose (or poisoning) of the drug, which was originally thought to be a stroke.[7]


  1. 1 2 "Инструкция по применению препарата Но-шпа® // No-Spa® (tablets) Full Prescribing Information". National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8.
  2. Padubidri V and Anand E. Title Textbook of Obstetrics. BI Publications Pvt Ltd, 2006 ISBN 9788172252236
  3. "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved 9 August 2014.
  4. Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
  5. No-Spa - Drugs.com No-Spa contents
  6. Drotaverine overdose (case report) Reactions Weekly, Volume 1481 (1), page 17.
  7. Silence, lack of will, indifference (Russian, Chess-News)
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