Clinical data
AHFS/ International Drug Names
Routes of
ATCvet code QN01AX91 (WHO) QN05AD90 (WHO)
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 4 hours
CAS Number 1649-18-9 N
PubChem (CID) 15443
ChemSpider 14695 YesY
KEGG D02620 YesY
Chemical and physical data
Formula C19H22FN3O
Molar mass 327.396 g/mol
3D model (Jmol) Interactive image
Melting point 90 to 95 °C (194 to 203 °F)
 NYesY (what is this?)  (verify)

Azaperone (Stresnil, Fluoperidol) is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. It is used mainly in pigs and elephants. [1] More rarely it may be used in humans as an antipsychotic drug, but this is uncommon. Use in horses is avoided as adverse reactions may occur.

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression which may be why it is rarely used in humans.

The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for anesthesia in combination with other drugs such as xylazine, tiletamine and zolazepam. Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals such as elephants.


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