Clinical data
ATC code none
Legal status
Legal status
  • Investigative new drug (not yet approved by the FDA)
CAS Number 145231-45-4
PubChem (CID) 2790
ChemSpider 2688
Chemical and physical data
Formula C14H17ClN4S
Molar mass 308.83 g/mol
3D model (Jmol) Interactive image

Clobenpropit is a histamine H3 receptor antagonist.[1] It has neuroprotective effects via stimulation of GABA release in the brain.[2]

See also


  1. Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology. 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
  2. Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology. 563 (1-3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.

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