"Thionylan" redirects here. The thionyl halides should not be confused with "thionylan" and include thionyl fluoride, thionyl chloride, and thionyl bromide.
Clinical data
ATC code R06AC05 (WHO)
CAS Number 91-80-5 YesY
PubChem (CID) 4098
DrugBank DB04819 YesY
ChemSpider 3956 YesY
UNII A01LX40298 YesY
KEGG C11114 YesY
ECHA InfoCard 100.001.909
Chemical and physical data
Formula C14H19N3S
Molar mass 261.387 g/mol
3D model (Jmol) Interactive image

Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC.[1] It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action. Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM. All of these products were reformulated in the late 1970s when methapyrilene was demonstrated to cause liver cancer in rats when given chronically.[2]

See also


  1. The Birmingham Post Archive.
  2. Lijinsky, W; Reuber, M.; Blackwell, B. (1980). "Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride". Science. 209 (4458): 817–819. doi:10.1126/science.7403848. PMID 7403848.

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